Effect of Polychlorinated Dibenzofuran on the Retention of Polychlorinated Biphenyl Isomers in the Liver and Adipose Tissue of Mice

作者：Shinjiro Hori, Takashi KASHIMOTO, Nobuharu Kunita · 发表于：Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) · 年份：1982 · DOI：10.3358/shokueishi.23.167 · 被引用次数：14 · 研究领域：Pesticide Exposure and Toxicity、Carcinogens and Genotoxicity Assessment

Toxic oil that caused the disease called Kanemi “Yusho” contained polychlorobiphenyl (K-PCB) and polychlorodibenzofuran (K-PCDF). K-PCB and K-PCDF were separated from the toxic oil, and administered to two groups of mice orally. K-PCB (15.4μg/mouse/day) or a mixture of K-PCB and K-PCDF (15.4μg+1.0μg/mouse/day) was administered every day for 7 consecutive days. In both groups the concentration and biological half-life (B. H. L.) of each PCB isomer were estimated in the liver and adipose tissue.The PCB isomers containing 4--7-chlorinated compounds showed the highest concentrations in the liver in both groups 1 day after the last oral administration. In the adipose tissue of both groups, 4- and 5-chlorinated PCBs exhibited the highest concentration on day 1, and 6- and 7-chlorinated PCBs on day 10.The CB% of each PCB isomer (the concentration of each PCB isomer relative to that of the total PCB isomers as a percentage) was examined on day 1 in the K-PCB group. In both liver and adipose tissue, the total CB% of 4- and 5-chlorinated PCBs containing 2, 4-3′, 4′-tetrachlorobiphenyl (peak 9), 3, 4-2′, 4′, 5′-pentachlorobiphenyl (peak 25) and 3, 4-2′, 3′, 4′-pentachlorobiphenyl (peak 28) as the main components was 66.2% in adipose tissue and 57.3% in the liver. On day 50, however, the total CB% of 6- and 7-chlorinated PCBs containing 2, 4, 5-2′, 4′, 5′-hexachlorobiphenyl (peak 29), 2, 3, 4-2′, 4′, 5′-hexachlorobiphenyl (peak 32), 3, 4-2′, 3′, 4′, 5′-hexachlorobiphenyl (peak 47) and 2,...