Polyketides with New Delhi Metallo-β-lactamase 1 Inhibitory Activity from Penicillium sp.

作者：Maoluo Gan, Yufeng Liu, Yinlei Bai, Yan Guan, Li Li, Rong‐Mei Gao, Weiying He, Xuefu You, Yuhuan Li, Liyan Yu, Chunling Xiao · 发表于：Journal of Natural Products · 年份：2013 · DOI：10.1021/np4000944 · 被引用次数：41 · 研究领域：Microbial Natural Products and Biosynthesis、Tannin, Tannase and Anticancer Activities、Enzyme Production and Characterization

Three new polyketide compounds (1-3), a new quinolone alkaloid (4), and seven known polyketide derivatives were identified from the cultures of Penicillium sp. I09F 484, a strain isolated from the rhizosphere soil of the plant Picea asperata from Kanas Lake, Xinjiang, China. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of 1 and 4 were established by quantum chemical time-dependent density functional theory electronic circular dichroism calculation and Marfey's method, respectively. Compounds 1 and 2 displayed inhibitory activity against New Delhi metallo-β-lactamase 1 with IC₅₀ values of 94.9 and 87.9 μM, respectively.