Managing Depression in Medical Outpatients

作者：Mary A. Whooley, Gregory E. Simon · 发表于：New England Journal of Medicine · 年份：2000 · DOI：10.1056/nejm200012283432607 · 被引用次数：379 · 研究领域：Treatment of Major Depression、Mental Health Treatment and Access、Schizophrenia research and treatment

Depression is second only to hypertension as the most common chronic condition encountered in general medical practice.1 At least 1 in 10 outpatients has major depression, but most cases are unrecognized or inappropriately treated,24 leading to loss of productivity, functional decline, and increased mortality.59 Appropriate therapy improves the daily functioning and overall health of patients with depression.10,11 DiagnosisMajor depression is defined by depressed mood or loss of interest in nearly all activities (or both) for at least two weeks, accompanied by a minimum of three or four of the following symptoms (for a total of at . . .