Two-year follow-up of a Chinese sample at clinical high risk for psychosis: timeline of symptoms, help-seeking and conversion

作者：Tianhong Zhang, Houyan Li, Kristen A. Woodberry, Lihua Xu, Yingying Tang, Qian Guo, HuiRu Cui, Xukang Liu, Annabelle Chow, Chensuizi Li, Kai Jiang, Z. P. Xiao, Larry J. Seidman, Jin-Yang Wang · 发表于：Epidemiology and Psychiatric Sciences · 年份：2016 · DOI：10.1017/s2045796016000184 · 被引用次数：75 · 研究领域：Schizophrenia research and treatment、Mental Health and Psychiatry、Mental Health Treatment and Access

BACKGROUND: Chinese psychiatrists have gradually started to focus on those who are deemed to be at 'clinical high-risk (CHR)' for psychosis; however, it is still unknown how often those individuals identified as CHR from a different country background than previously studied would transition to psychosis. The objectives of this study are to examine baseline characteristics and the timing of symptom onset, help-seeking, or transition to psychosis over a 2-year period in China. METHOD: The presence of CHR was determined with the Structured Interview for Prodromal Syndromes (SIPS) at the participants' first visit to the mental health services. A total of 86 (of 117) CHR participants completed the clinical follow-up of at least 2 years (73.5%). Conversion was determined using the criteria of presence of psychotic symptoms (in SIPS). Analyses examined baseline demographic and clinical predictors of psychosis and trajectory of symptoms over time. Survival analysis (Kaplan-Meier) methods along with Log-rank tests were performed to illustrate the relationship of baseline data to either conversion or non-conversion over time. Cox regression was performed to identify baseline predictors of conversion by the 2-year follow-up. RESULTS: In total 25 (29.1%) of 86 completers transitioned to a psychotic disorder over the course of follow-up. Among the CHR sample, the mean time between attenuated symptom onset and professional help-seeking was about 4 months on average, and converters develop...