Spontaneous Perforation of the Esophagus; Experimental Study

作者：E. L. Brackney, Gilbert S. Campbell, Alan P. Thal, Owen H. Wangensteen · 发表于：Experimental Biology and Medicine · 年份：1955 · DOI：10.3181/00379727-88-21571 · 被引用次数：24 · 研究领域：Tracheal and airway disorders、Esophageal and GI Pathology、Dysphagia Assessment and Management

1. Esophageal perforations, similar in many respects to the so-called “spontaneous” perforations of the esophagus seen in humans, can be caused in dogs by ligation of the outlet of the stomach followed by intramuscular administration of histamine-in-beeswax. 2. The incidence of esophageal perforation is far higher following pyloric obstruction in dogs that have a double-barrelled cervical esophagostomy prior to pyloric ligation. Presumably this is due to the loss of the protective effect of the saliva. 3. Excision of the acid-secreting segment of the stomach not only prevents esophageal perforation following pyloric ligation, but also completely prevents the development of any esophagitis.