Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT)

作者：Julie A Bernhardt, Leonid P. Churilov, Fiona Ellery, Janice Collier, Jan Chamberlain, Peter Langhorne, Richard I. Lindley, Marj Moodie, Helen Dewey, Amanda Gay Thrift, Geoffrey Alan Donnan, Julie Bernhardt, Leonid P. Churilov, Janice M. Collier, Helen Margaret Dewey, Geoffrey Alan Donnan, Fiona Ellery, Peter Langhorne, Richard Lindley, Marjory Moodie, Brooke Parsons, Amanda Gay Thrift, Geoffrey Alan Donnan, Helen Margaret Dewey, Julie Bernhardt, Peter Langhorne, Marjory Moodie, Brooke Parsons, Main Investigators MIs, Bent Indredavik, Torunn Askim, Phillip Bath, Christopher Bladin, Christopher Michael Reid, Stephen G. Read, Cathy Said, Sandy Middleton, Judith H. Frayne, Velandai K. Srikanth, Australia: Julie Bernhardt, Helen Dewey, Julie Bernhardt, Geoffrey Alan Donnan, Amanda Gay Thrift, Rob Carter, Richard Lindley, Julie A Bernhardt, Geoffrey Alan Donnan, Richard I. Lindley, Amanda Gay Thrift, Peter Langhorne, Marj Moodie, Helen Margaret Dewey, Leonid P. Churilov, Peter Langhorne, Peter Langhorne, Olivia Y. Wu, Julie Bernhardt, Matthew Walters Claire Ritchie, Lorraine Smith, Peter Langhorne, Olivia Y. Wu, Anne Ashburn, Helen Rodgers, Julie Bernhardt, Peter Langhorne, Anne Ashburn, Julie A Bernhardt, Helen J. Rogers, Olivia Y. Wu, Sheila Lennon, Sheila Lennon, Michael Power, Julie A Bernhardt, Shahul Hameed V, Shahul Hameed V, Pavanni Ratnagopal, Peter A.C. Lim, Julie Bernhardt, Dawn May Leng Tan, Leonid P. Churilov, Tim R. Brewer, Janice Collier, Nick Haritos, E Leong, Cecilia Li, Caesar NayWin, Marcus B. Nicol, Liudmyla Olenka, Li Chun Quang, Marjory Moodie, Rob Carter, Silvia Hope, Lauren Sheppard, Kiusiang Tay-Teo, Olivia Y. Wu, Toby Borland Cumming, Thomas K. A. Linden, Karen Borschmann, Jan Chamberlain, Janice M. Collier, Toby Borland Cumming, Fiona Ellery, Teresa Occhiodoro, Helen Palfreeman, Tara L. Purvis, Bernadette Sirgo, Nick Tiliacos, John Van Holsteyn, Henry H. Zhao, Beverly Armstrong, Louise Craig, Fiona P. Graham, Lynn A. Legg, Rosemary H. Morrison, Heather Moorhead, Lorraine O’Donohue, Susan Rogers, Myra D. Smith, Denise Forshaw, Jane E Fitzgerald, Evelyn Hibbert, R Melling, S. Petrolo, Tara L. Purvis, H Williamson MIs, P Adams, L Augoustakis, S Batcheler, Sue C. Berney, Vera Cobani, B Cohen, Helen Margaret Dewey, Stefania Di Gangi, N Giofre, Christopher James Gordon, L Hegarty, M Hindson, F Horváth, Scott E. Kalinowski, Appie H. Kleine, Sharon Kramer, J Lawrence, S Lindquist, Nicola S. Logan, A. A. Macdonell, J Matlioski, N McDonough, Susan V. McLennan, Mike McNamee, Laura V. Miller, Christina Nall, Elizabeth A. Nelson, K Ng, Z Nicholas, Caitlin Nunn, Katharine R. Owen, Emma Plant, Louise A Proud, Denise Desiree Bi Si Quah, K Rodway, S Sertori, Vanessa M. Sheldon, Lance Sherry, Sally Speare, K Stansfeld, N Studden, Zheyi Teoh, Lucy E. TWIST, G Velupillai, L Walker, Kylie Janine Wall, Anne B. Warwick, R Wharrie, John W. Wilson, Hannah M. Worboys, David Young, J Ancliffe MI, M Bryant, Bethany Doran, Michael John Field, P Fogliani, A Háber, Graeme J. Hankey, Delia V. Hendrie, V Jackaman, A. S. Jacobsen, S Jose, Reece C. C. Lim, Renée M. St. Louis, S. Nanthakumar, Scott Pain, Anne Power, B Rappeport, John Reynolds, L Smith, S Tombe, Andrew Wesseldine, T West, Kristie E.N. Clarke, H Maccanti, Linsey C. Marr, Sandra Plumb, Jeremy Quiney, L Werner MIs, E Abeykoon, W Apirutvorrachod, Luciano Attard, S Behanan, D Brown, K. D. Buchanan, Donna Butler, M Camac, Stephen M. Davis, D Diocera, N Y Gan, C Gendre, Jacqueline Germaine, Peter J. Hand, L Maurenbrecher, J McCulloch, S Mcritchie, M Ong, R Pachett, Lauren Pesavento, HENRY M. POWER, Richard B. Reilly, Michelle Sawers, G Silva, C Stevens, Lee K. Taylor, Tracy Timms, Melissa Ugalde, Audrey Vardy, Jana Wallace, S Walsh, Erica Whatley, Edward Winter, Mark A Baxter, Michelle Davis, Leyla Mıs, Ernest Gerard Butler, Kristin M. Caspers, Elizabeth Jackson Coulter, S Shaw, Fiona Kent, H. Lambert Lack, F Leavold, J Lord, Jill Francisco, Rajiv Mohanraj, R Nelson, T O'Neill, R. M. Otto, Jane Parker, Vaughan W. Rees, B Stevens, Ru-Rong Mi, Richard I. Lindley, Jessica Bindra, Rohit Dongre, N Downey, Michael J. Ferris, Linda Gibson‐Young, R Gonzalez, M Kinniburgh, M. Lazaridou, D McCormack, Rajesh Kumar Singh, A Stepney, Y Tria, Kathleen E. Bainbridge, B Killey, R Sheedy MIs, O Aitchison, Lucy Bray, K Clatworthy, Sarah Coghill, Marissa Collins, L. Cornwall, Julian A. T. Dow, Peter Gates, Sarah Gillett, Niall Johnson, Sonia Joseph, K Kopelke, R Lam, R Levy, Nancy S. Lloyd, Stuart Logan, Gary Edward McPherson, M Newth, C Parsons, K Powles, M Rebis, T Samakowidic, Lauren Sanders, S Savickas, J Shrimpton, H Smith, L Smith, Jennifer Spehr, James L. Summers, George Taylor, Michael M. Thackeray, Bethanie E. Wilkinson, K Richardson MI, Judith H. Frayne, E. M. Barber, Lisa Bode, A Brakey, K Chand, Patricia Christin, Gretchen Crook, D Delrosario-Kelly, R Descallar, Anne F. Deutsch, S. Easo, Morag C. Farquhar, Paul Fergus, Jon Joseph Ford, Elizabeth Hamson, M Hlaing, Erica Hope, J Lacivita, James P. Laurenson, Karen Lock, N Ly, Kirsten McKay, Christopher Peter Mill, Kate Moloney, L Price, T R Terry, A Tyers, Stephan Willems, Rachel Woolstencroft, N Crawshaw, Julie A Luker, Caroline Wood, S Choat MIs, Colin Archer, Derek A. Benham, Michael S. Billinger, M. Bronca, S Curchin, Colleen I. Dickie, Mark S. Dixon, David Douglass, M Enomoto, Kris Ernst, Louis F Fries, Shane S. George, E Green, Laura Kate Hamilton, Zena Leah Harris, Todd R Heard, G Hunt, Nigel Balfour Jamieson, M. Mackenzie, H McKearney, B Oermann, Claire Louise O’Reilly, Thomas A. Pearson, Neil B. Reid, L Rodda, D Scutcheon, Cas Simons, R Smith, Larry R. Tait, J Troake, David C. Usher, Laura M. Mackey, Tomasz Miś, Christopher Abela, S. Ashoka, C Chen, T Cheng, Victor N. Chong, S Cooke, Alex Fok, L Galang, C Grant, S Karageorge, K Kat, Lundy Keo, Bonsan B. Lee, Anna Louisa Luscombe, J Mackay, M Minett, Jenifer E. Mizen, P Nim, N Nunlist, Vijay S Patel, Manoji Pathirage, A Paton, M Pombuena, Nilminie Rathnayake, Lesley Elizabeth Rhodes, Manuel Sequeira, Suzanne Smart, Seneviratne Somaratne, Noor-ul-Huda Maria, Lisa S. Talbot, R Tecle, M Shannon, R Gerraty MIs, Stephen John Allen, R Boyle, N Fatchen, Nella Hendley, Anna J. Hyde, Mehmet Turan İnal, P Kalubowilage, Mauricio Fernández Laverde, K Lawless, Angus Kennedy McFadyen, K Peters, Christopher William Pugh, C Qin, J Robertson, Shania N. Smee, R Tomlinson, V Wang, F Williams, D. W. Woolley, R Yawieriin, Nicola C. Austin, Suzanne Pomfret, M Tinsley MIs, L Allport, C Ang, Laura Catherine Armitage, E Blundell, Aoife Courtney, M Dela Costa, T Devi Thapa, Previn Diwakar, M Dulleh, J Francis, P Cic, G Gellie, C Gill, D James, S Lee, Tobias Mai, Klaudia Majcher, Colin Ashley Mawson, Gary E. Newton, N Qiu, E Ragonton, L. Roberts, H Saitamis, L Stanwell, L Ting, P Xu, L Yin, V Crosby MI, K Broadhead, Jarrod E. Church, Rory Collins, Katelin A. Everitt, Miles Fisher, Karin Hochmuth, N Jones, Anna Lieschke, Eoghan M. McCarthy, C McGlone, D Morey, Donald Neilson, S Spry, Melanie A. Vile, Rohan Grimley, D Rowley MIs, Ingrid C. M. Rosbergen, Elizabeth Stephanie Ahern, L Anderson, Jillian Boreham, Ruth Devin, Rory Doolan, Melissa K. Van Dyke, Lori A. Griffiths, K. Guest, D Hecita, N Kendal, Jan Jens Koltermann, Martha Q. Lacy, S Lebeter, D Lloyd, Mary Matthews, Clyde E. McAuley, Alex Pollock, Mark Pyke, T.B. Rogers, Sierra Street, George Styles, A Tampiyappa, John H. Trinder, T Verral, Karen Zell Walker, C White, T Beckwith, L Cormack MIs, J Arriagada, C Babenschneider, David Blacker, Stephen P. Bennett, Susan Jane Connor, J Cowmeadow, N Daniel, Gillian Edmonds, Michael J. Faulkner, M. García-Vega, K. Krüger, B Martial, Patton H. McGinley, H Mountford, Vernon Riley, N Smith, F Stepan, S. Tilley, S Whisson, P Groot MI, James Bailey, Karen Ballinger, Colin Bell, Brian Camilleri, C Charnley, David Crabbe, STANLEY G. CROSSLAND, N Edirimanna, C Fitzgerald, C Gibbins, Jonathan M. Gibbs, Kathryn Hirst, Ann R. Kennedy, Erwin Klose, Kiera McDowall, S Miller, Robert O. Morgan, Anne M. Noonan, Mal North, M Oliver, Katherine L. Richards, T Russell, Nick Scott, A Shlanski, A E Traynor, S Smith MI, Richard Adams, Ceri Banks, Katherine T. Burke, Sally Hewat, Benjamin S. McKenna, M McKimmie, L Polmear, M Traumanis, Shinelle Whiteman, V Bramah, R Errey, Mark Halpin, V Molan, Danielle Wheelwright, Nick M Wilson, W Zhang MIs, Mayur V. Bakshi, Susanne Bracher, M Bryant, William C. Byrnes, Timothy A. Denton, N DeVries, Patty Fay, Paul F. Galbraith, Tim Gallaher, Omar Haidar, Katie Holgate, K Hozack, Nicholas Jackson, Sarah Kipps, Susan A. Lerner, Romesh Markus, Roula Merheb, Carolyn Naismith, Geraldine Nolan, R Odelli, Kathleen Raquel Page, Paradi Sangvatanakul, Thomas Simpson, P van Vliet, Katharina Walch, S Walker, Tomomi Yasue, Gustavo Mi, Rebecca R. Baker, K. L. Cousins, Malcolm Fairbrother, Kate Hutchinson, M. Maclean, Eamonn Richard Maher, Dean E. Mills, S Ohlback, John Sturm, M Tooth, J Watkins, J Cramb MI, Prescott Atkinson, J Conrad, Daniela Fichera, S Follent, Carlene Gilbert, Mary Herzig, Siegfried Köhler, Stuart R. McCracken, Linda M. Nunan, S Roberts, Julia M. SHELLEY, S Varendorff, Andrew Keith Wills, Andrew D. Moore, A Robertson MIs, J Britton, Andrea Burgess, Thomas D. Coates, Janet B. Croft, Ed Greening, J Holland, Paul E. O’Brien, R. W. Strong, L Tighe MI, S Bilston, James A Black, Kristine Rivera, Isabel Dwyer, S Gissane, K Heckenberg, Susan Jackson, A Maclagan, L. O'Hare, H Patel, J Pearce, Christopher N. Scanlan, Keith Seymour, Matthew Symington, A Tyers, Alasdair Waite, Karel J. Wiesner, Owen M Katalinic, M Spear MIs, P. Brown, E Difuntorum, Sarah C. Gilbert, J Henderson, D James, Heidi Janssen, Emma L. Lane, Sarah A. Lowndes, Daniel J. Smıth, Sandra Claire Thompson, D Weaver, Stuart M. Weston, Stephen Wright, Shanice Cox, C Tse MIs, Juan Copajira Adrian, Michael J. Doughty, J Kok, Ryan P. McGrath, Tom Morris, Audrey Pickup, Emma Ray, R Richardson, Michael L. Sims, C Thompson, Kim Hoang Trinh, N Walton, Frank Whittaker, Peng Mi, Julia Burrows, M Dawson, D Griffiths, G Harris, P Kavalieros, Brian J. O'Brien, K Roberts, Jennifer D. Watkins, Caroline P. Whyatt, Andrew S. McRae, G Wavish MIs, F Anos, J Armstrong, Eric Hoi Kit Au, P. Alan Barber, Chris J Bates, Mary Catherine P. Bertulfo, Ashley E. Boggs, F. Michael Burgess, K Cassels-Brown, M Chiu, Sabrina Jane Dass, Nicola Duff, J Farrell, W Foster, D Fuertez, C Gadhvi, Shane S. George, Andrew Green, L Harvey-Fitzgerald, Lena Hau, Louise Hayward, D. Holman, K Huggins, M Jacobs, Ann Mary John, H Kaur, T Lagerstedt, J Lee, R Llenes, Laura Lyons, S Magandi, Mary Martin, Sowmya Mathew, Thomas Aerathu Mathew, David W. McKellar, Elizabeth Moss, KL Nand, K Nicol, F. Ross Peterson, Ananda Shiva Prasad, K Quick, E Revell, S Roy, Joanne L. Ryan, Nasser Samadi, Benjamin J. Scrivener, J Slow, Sasha Job Tharakan, Jordyn N. Torrens, E van Bysterveldt, C Villaluz, Seungmi Yang, MA Katijjahbe, GK Sing, A. Aida Azlina, MI Azmi, MH Efri, AZ Fadilah, H Fathuddeen, Heni Haryani, H. Hussien, M Izuani, ZC Man, Cao Ying, KM Mashitoh, Ayeetin Azah, MI Norlinah, I Norliza, KB Ravinder, R Rohaizah, K Rosnita, A R Rozita, Jihan Safwan, Ramesh Sahathevan, I.M. Shahrul, SM Sharifah, HJ Tan, WY Wan Nafisah, Y. K. Yee, MA Zaharah, AS Zunaidah, Darius Tan, MT Ahmad, S Hameed MIs, MFB Bakari, Jonathan A. Britto, Jianjun Chen, S Choo, M Faizal, FK Fong, Seok‐In Hong, Johar M. Jaafar, Z Ke, Gerald Choon‐Huat Koh, CK Lee, YF Lee, P Lim, GM Lim, SH Ninhadi, G B Ong, T Pei Pei, V Penero, Norsyamlina Che Abdul Rahim, Pavanni Ratnagopal, Khalid Al Saleh, HC Seow, E Sim, Chee‐Kiat Tan, Priscilla Tay, Irene Teo, Shamala Thilarajah, PHJ Wong, WP Wong, Swan Sim Yeap, M Macleod MI, A Anderson, Kirsten Anne Armstrong, Kristin Baird, David J.K. Balfour, Matthew Boyd, Jan Cameron, Christopher James Carswell, C Clanachan, L Cuthill, I Devoy, S Forsyth, James R. Gavin, M Hughes, Emily H. Marr, Sybil A. McAuley, E McCagherty, Katie Elizabeth McCallum, Natasha McDonald, Caroline McGhee, TA McIntyre, Lenore Noonan, Amanda E. Smart, RD Walshe, Donghu Mi, John D. Allison, G Ball, S Board, Huw Brunt, Clare Buckley, Cliona Carroll, David Hayward, Thomas H. Hutchinson, Elizabeth A. Jones, Elizabeth G. Keeling, Elisabeth Breese Marsh, N Mead, H Smith, Carinna Vickers, Barbara Williams-Yesson, D Wood, John J. Coyle, Maciej Miś, L Ackroyd, C Brown, Kate J. Donnan, Nigel P. Dyer, H Green, G Kilbride, Calum Nicholson, Mary E. Porteous, S Louw MI, AK Annamalai, Amina Barkat, Susan E. Crawford, M Fawcett, D P Harvey, Valerie Hogg, Ann‐Marie Hughes, Joanne L. Kemp, J Morrison, Kelley Storey, Teresa Thompson, Jacqueline Furnace, MJ Macleod MIs, James Bell, Katherine A. Bennett, M F Bruce, Robert Clarke, Helen Louise Cowie, Heather Gow, Janice Irvine, Anu Joyson, S MacDonald, Anne M. MacVicar, Nicholas M. Murphy, J Robertson, Christopher James Gordon, Joseph S. K. Kwan, Lyndell Redpath, K Saunders MIs, James Bell, Rebekah Burrow, Caroline Clarke, Cheryl A. Dickson, Gail Hann, Martha Heath, Simon Charles Heath, Andrew J. Hewett, Richard Lewis Humphrey, Barbara Longland, A. Guy. Orpen, Catherine Ovington, Joseph William Page, E Rogers, Kenneth E. Toombs, Rachel Howes, Arron Lacey, P Meakin MIs, D Ames, S Banerjee, Eva Beranová, Sarah D. Berry, Burke Mj, V Cassama, Kayleigh Collins, Jennifer Crow, A. Dunne, C Gomez, Adrian Hawkins, Kate Hellier, SA Howard, Arindam Kar, E Lambert, H Lee, C Mandri, Jack Moye, E Murtagh, J Pushpa-rajah, Jeff R. J. Richardson, TSachs, J Stilwell, Victoria Tilley, Peter Wilding, Nick M Wilson, E Feely, S Kirk MIs, Pamela B. Cassidy, Anthony J. Chalmers, C.M. Duguid, N Hughes, Jennie Hutton, Karen G. Lapsley, J Lee, Ann Marie Murray, Louise C Weir, Murray L. Whitelaw, Mark Barber, Dominika Mis, H Armit, Clare E. Devlin, Rachel K. Duncan, Christian Riis Forman, Karen Frame, Lauren Hogg, Peter J. McLeod, R McWhinney, Judi A. Porter, M. J. Purves, L. A. H. Snowball, Boya Mi, L Ferson, Mary M. Gibson, Scarlett Gillespie, Nandini Ignatius, T Kane, J Kwant, Mary Matthews, C Rosaleen McCallion, Chris F. McConville, Michael McDowell, Cora McNally, L Moore, P Murphy, Ariel Nesbitt, J Newell, M Power, E Reid, K Robinson, C Charnley, M James MIs, Seb Bacon, N. A. Booth, Angela Bowring, Lucy Boxall, Jenni Burt, Julie Cageao, N Green, Karin Gupwell, Samantha Keenan, Hayley Kingwell, M Kryszkowska, J. Mortimore, Ben Peace, Caroline Roughan, G Gunathilagan, Julia Sampson, G Thomas MIs, T Allen, Giulia Danè, Katherine E. Harris, Stephanie L. Hart, Simon Jones, M Reader, Patrick J Browne, C McGoldrick, D Mullan MIs, Pauline Adair, J Armstrong, E. Beggs, Iris R. Bell, C Edwards, Liam Gilligan, Christine Kelly, M Kennedy, Jujju Jacob Kurian, L Leal, A McAtamney, E.L. McKay, Emer Rogan, Mark John Smyth, Eve J. Wiseman, J Vahidassr, Christopher Price, V Riddell MIs, Emma Bendix, Kimberly A. Craig, Richard R. Davison, Amy S. Harrison, A Smith, Vermeulen Mi, Kate E Ashton, Wikus Barkhuizen, A Daniel, Corrine Dickinson, H Durdu, Deborah M. Eastwood, Harriet Goddard, R Hodkin, J Howard, Carol Jeffs, Sean Joyce, C Kelly, Gillian D. Kerr, J Lanes, B Magnall, Michael J. McMahon, M. Anthony Moody, Simon J. Patton, Rebecca J. Taylor, A Watson, Keith Richard Mitchelson, L Mokoena MIs, Lydia Aird, Rachel Lakey, J. Murdy, Kristine Nelson, G Storey, R McGeown, S Tauro MIs, Richard R. W. Brady, Thomas L Holland, Margaret F. Kinnaird, L Maltman, Dianna C. Martin, K McCord, Sonia McKenna, Catherine Morgan, Caitlin S. Shannon, A Steele, Ivan Wiggam, S Appleby, Sean Brotheridge, Marcin Miś, Paul A.J. Bagot, Dorina Baston, Cathy Bennett, J. Featherstone, Christine Hare, Annie McCluskey, S Wade, R Worton, E Hakim, J Herman, T Norman MIs, Linda Beale, Erin M. Buckley, Kathleen Byrne, Maria Gasior, Brittany Noel Robles, C Smallwood, Stephanie Stevens, Mary V. Thomas, Victoria L. Williams, K Buck MI, Sarah Armstrong, V Brice, Amy Edwards, S Gething, A Griffiths, Thomas E. Hills, David William Howells, Simon P. Langdon, Scott Moseley, Graham A. Powell, G Reynolds, Bella Richard, E Scott, R White, Janelle A. Zebedee, M Walters MI, John Hunter Alexander, Linda Brand, E Colquhoun, A Hill, Duncan Macartney, Helen Macdonald, B Manak, H Morgan, Craig Ritchie, H Hunter MI, Timothy P. Blair, Merry Duffy, James E. Graham, Jon Scott, Trang T. Vu, P Yorston, Antonopoulou MI, Imtiaz Ahmed Shakir, Christopher Button, Michael Friend, Jill Greig, Brigid Hairsine, S Wade, Sheara T. Williamson, Guangda Mi, Temi Adedoyin, N Dayal, Sara Gawned, Rita Ghatala, Naomi Jeyaraj, Lourda Kerin, L Montague, Chukwuka Orefo, J. N. O'Reilly, J Styles, Sarah Trippier, Caroline Watchurst, Fran Watson, J Hunt, R Latif MIs, Christopher D. Barrett, Jason Douglas Cox, Fiona Hammonds, K Quick, K Robinson, A Skinner, C R Vernon, Seona Burgess, T Elder-Gracie MIs, C Browne, W Cameron, Valerie Coleman, C Fulgencio, Linda Gibson‐Young, Paul G. Halliday, Dominic C. Heaney, Luana C. Main, K McGavin, Gillian E Mead, F. G. PROUDFOOT, Adam Redpath, Colin R. Rodger, S. Mark Scott, Katie Robinson, K Mason MI, Leslie C. Baxter, Adam S. Bryce, M Halkett, Jo E. B. Halliday, Anita M. McAllister, Matthew E. McGuiness, M. Munro, Adelaide S. Robb, A Thompson, B Tougher, J Weadon, J. Young, Chung Mi, M McParland, S Boyle, Ben E. Byrne, Liam Comiskey, J Gilpin, S Gilpin, Adam Harris, S Harshaw, John Patrick Haughey, F. McArdle, L. Mcconnell, E McEneaney, Michael R. Millar, Margit Alt Murphy, Joanna Tilley · 发表于：Neurology · 年份：2016 · DOI：10.1212/wnl.0000000000002459 · 被引用次数：220 · 研究领域：Stroke Rehabilitation and Recovery、Acute Ischemic Stroke Management、Balance, Gait, and Falls Prevention

OBJECTIVE: Our prespecified dose-response analyses of A Very Early Rehabilitation Trial (AVERT) aim to provide practical guidance for clinicians on the timing, frequency, and amount of mobilization following acute stroke. METHODS: Eligible patients were aged ≥18 years, had confirmed first (or recurrent) stroke, and were admitted to a stroke unit within 24 hours of stroke onset. Patients were randomized to receive very early and frequent mobilization, commencing within 24 hours, or usual care. We used regression analyses and Classification and Regression Trees (CART) to investigate the effect of timing and dose of mobilization on efficacy and safety outcomes, irrespective of assigned treatment group. RESULTS: A total of 2,104 patients were enrolled, of whom 2,083 (99.0%) were followed up at 3 months. We found a consistent pattern of improved odds of favorable outcome in efficacy and safety outcomes with increased daily frequency of out-of-bed sessions (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.09 to 1.18, p < 0.001), keeping time to first mobilization and mobilization amount constant. Increased amount (minutes per day) of mobilization reduced the odds of a good outcome (OR 0.94, 95% CI 0.91 to 0.97, p < 0.001). Session frequency was the most important variable in the CART analysis, after prognostic variables age and baseline stroke severity. CONCLUSION: These data suggest that shorter, more frequent mobilization early after acute stroke is associated with greater od...