Production of Dietary Vit. K Deficiency in the Rat.

作者：M.S. Mameesh, B. Connor Johnson · 发表于：Experimental Biology and Medicine · 年份：1959 · DOI：10.3181/00379727-101-24982 · 被引用次数：70 · 研究领域：Vitamin K Research Studies、Antioxidant Activity and Oxidative Stress

A diet is described which produces a severe Vit. K deficiency in the rat in less than 10 days. The deficiency was manifested by prolonged plasma prothrombin times and hemorrhages. Daily menadione supplementation protected rats from the deficiency. Coprophagy appeared to be the means by which Vit. K synthesized by the intestinal microflora becomes available to the rat.