Radiation Sensitization of Bacterial Spores by cis-Dichlorodiammineplatinum(II)

作者：Robert C. Richmond, E. L. Powers · 发表于：Radiation Research · 年份：1976 · DOI：10.2307/3574476 · 被引用次数：68 · 研究领域：Radioactive element chemistry and processing、Inorganic and Organometallic Chemistry、Chemical Synthesis and Characterization

The x irradiation of B. megaterium spores in aqueous suspension in the presence of cis-dichlorodiammineplatinum(II) (CPCA) results in biphasic survival curves showing pronounced increases in radiation sensitivity in N/sub 2/ , O/sub 2/, and in N/sub 2/O in the low-dose portion of the response. In N/sub 2/, the degree of CPCA-induced sensitization fully equals that due to O/sub 2/ alone. In the presence of O/sub 2/ and N/sub 2/O, the added component of sensitization is half that obtained under N/sub 2/ saturation. Additional results are also obtained in the presence of hydroxyl radical scavengers, and in the presence of N/sub 2/O. These results are additionally significant considering that CPCA has been successfully used in animal studies as an antitumor drug.