A Method for Producing Chronic Cardiac Failure in Dogs.

作者：A. Clifford Barger, G. S. Richardson, Benson B. Roe · 发表于：Experimental Biology and Medicine · 年份：1950 · DOI：10.3181/00379727-73-17595 · 被引用次数：24 · 研究领域：Cardiac Valve Diseases and Treatments、Mechanical Circulatory Support Devices、Cardiovascular Conditions and Treatments

SummaryA form of progressive, chronic, “right-sided” cardiac failure has been produced in dogs by tricuspid valve avulsion and pulmonary artery stenosis. Three dogs so treated developed congestive failure with elevated auricular pressure and distended veins, decreased work tolerance, hepatomegaly, ascites, tachycardia at rest, and a relatively fixed heart rate during exercise. Studies of 2 of the hearts in the heart-lung preparation indicate clearly that cardiac insufficiency was present.