TRIM29 overexpression is associated with poor prognosis and promotes tumor progression by activating Wnt/β-catenin pathway in cervical cancer

作者：Rui‐Hua Xu, Jing-Ye Hu, Tiansong Zhang, Chao Jiang, Hui‐Yun Wang · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.8686 · 被引用次数：47 · 研究领域：Cancer Mechanisms and Therapy、Peptidase Inhibition and Analysis、Galectins and Cancer Biology

// Rui Xu 1, 2 * , Jingye Hu 3 * , Tiansong Zhang 4 , Chao Jiang 1, 2 , Hui-Yun Wang 1, 2 1 State Key Laboratory of Oncology in South China, Guangzhou, China 2 Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China 3 Department of Basic Medicine, Guiyang College of Traditional Chinese Medicine, Guiyang, China 4 Gynecology and Obstetrics Department, Women and Children’s Medical Center, Guangzhou, China * These authors contributed equally to this work Correspondence to: Hui-Yun Wang, email: wanghyun@mail.sysu.edu.cn Keywords: TRIM29, prognosis, proliferation, metastasis, cervical cancer Received: December 21, 2015     Accepted: March 28, 2016     Published: April 12, 2016 ABSTRACT Dysregulation of TRIM29 has been reported to be involved in tumorigenesis, but the role of TRIM29 in cervical cancer is unclear. In this study, we first examined TRIM29 expression and found that TRIM29 mRNA and protein expression was upregulated in cervical cancer tissues when compared with the matched adjacent cervical tissues. We further detected TRIM29 protein with immunohistochemistry in 150 paraffin-embedded samples from early-stage cervical cancer patients. The results showed that high expression of TRIM29 was significantly associated with pelvic lymph node metastasis ( p =0.002), advanced FIGO stage ( p =0.026) and post-operative recurrence ( p <0.001). Patients with high expression of TRIM29 h...