Short communication: N-Acetylcysteine-mediated modulation of antibiotic susceptibility of bovine mastitis pathogens

作者：Feng Yang, Leying Liu, Xue-peng Li, Jianguang Luo, Zhe Zhang, Zuoting Yan, S.D. Zhang, H.S. Li · 发表于：Journal of Dairy Science · 年份：2016 · DOI：10.3168/jds.2015-10756 · 被引用次数：38 · 研究领域：Milk Quality and Mastitis in Dairy Cows、Biopolymer Synthesis and Applications、Microbial infections and disease research

The aim of this study was to investigate the effects of N-acetylcysteine (NAC) on antibiotic susceptibility of bovine mastitis pathogens including Staphylococcus aureus, Streptococcus dysgalactiae, Escherichia coli, and Streptococcus agalactiae. Minimum inhibitory concentrations (MIC) were tested by the agar-based E-test method. The presence of 10mM NAC reduced the MIC of penicillin and ampicillin but enhanced the MIC of erythromycin and ciprofloxacin for all of the strains. In addition, NAC-mediated modulation of MIC of kanamycin, tetracycline, and vancomycin was diverse, depending on the target bacterial pathogen and antibiotic being used. The results suggest that NAC is an important modulator of antibiotic activity against the major bovine mastitis pathogens.