Prognostic value of wait time in nasopharyngeal carcinoma treated with intensity modulated radiotherapy: a propensitymatched analysis

作者：Yu‐Pei Chen, Yan‐Ping Mao, Wenna Zhang, Lei Chen, Ling‐Long Tang, Wen‐Fei Li, Xu Liu, Guan‐Qun Zhou, Rui Guo, Ying Hao Sun, Tiebang Kang, Mu‐Sheng Zeng, Jun Ma · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.7789 · 被引用次数：32 · 研究领域：Head and Neck Cancer Studies、Lung Cancer Treatments and Mutations、Cholangiocarcinoma and Gallbladder Cancer Studies

// Yu-Pei Chen 1, * , Yan-Ping Mao 1, * , Wen-Na Zhang 1, * , Lei Chen 1 , Ling-Long Tang 1 , Wen-Fei Li 1 , Xu Liu 1 , Guan-Qun Zhou 1 , Rui Guo 1 , Ying Sun 1 , Tie-Bang Kang 1 , Mu-Sheng Zeng 1 , Jun Ma 1 1 Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China * These authors contributed equally to this work Correspondence to: Jun Ma, e-mail: majun2@mail.sysu.edu.cn Keywords: nasopharyngeal carcinoma, wait time, intensity modulated radiotherapy, prognosis, propensity score matching Received: October 08, 2015 Accepted: January 29, 2016 Published: February 29, 2016 ABSTRACT The aim of this study was to determine the prognostic value of wait time from histological diagnosis to primary treatmen for nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT). Between October 2009 and February 2012, a total of 1672 NPC patients were retrospectively analyzed. A cutoff value of > 4 weeks was used to define prolonged wait time. Matched patients according to the wait time were identified using propensity score matching (PSM), which was also used to identify matched patients for subsequent stratified analyses. Differences in progression-free survival (PFS), overall survival (OS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRFS) were estimated using the Kaplan–Meier method and Cox proportional hazards ...