Prediction of the response of ocular adnexal lymphoma to chemotherapy using combined pretreatment dynamic contrast-enhanced and diffusion-weighted MRI

作者：Pengde Guo, Zhaohui Liu, Fei Yan, Jingwen Wang, Liqiang Wei, Han Lv, Zhenchang Wang, Junfang Xian · 发表于：Acta Radiologica · 年份：2016 · DOI：10.1177/0284185116631181 · 被引用次数：12 · 研究领域：Lymphoma Diagnosis and Treatment、MRI in cancer diagnosis、Breast Lesions and Carcinomas

Background There are no established biomarkers predictive of the efficacy of treatment for ocular adnexal lymphoma (OAL). Purpose To evaluate the effectiveness of pretreatment dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) in predicting the response of OAL to chemotherapy. Material and Methods Twenty-one patients, who were pathologically diagnosed with OAL, were retrospectively analyzed. According to the National Comprehensive Cancer Network (NCCN) response evaluation criteria for non-Hodgkin’s lymphoma, patients were divided into responders (n = 14) and non-responders (n = 7). The volume transfer constant (K trans ), rate constant (K ep ), extracellular extravascular volume fraction (Ve), and apparent diffusion coefficient (ADC) were computed. Two independent-sample tests were applied for statistical analysis. For significantly different parameters, receiver-operator characteristics curve analysis was performed. Results The K trans value (min −1 ), K ep value (min −1 ), and ADC value (10 −3 mm 2 /s) were 0.76 ± 0.36 vs. 0.47 ± 0.18 (mean ± SD), 4.43 ± 1.29 vs. 3.14 ± 1.37, and 0.51 ± 0.12 vs. 0.66 ± 0.15, respectively, in the responders and non-responders groups. Significant differences were found between the two groups regarding these parameters ( P < 0.05). However, no significant difference was observed in Ve (min −1 ) between the groups ( P > 0.05). K trans , K ep , and ADC had a moderately predictive sensitivity...