Resistance trends among clinical isolates in China reported from CHINET surveillance of bacterial resistance, 2005–2014

作者：Fupin Hu, Yan Guo, Demei Zhu, F. Wang, Xiaofei Jiang, Y.-C. Xu, Xiaowei Zhang, Chunbai Zhang, Ping Ji, Yi Xie, Mei Kang, Changquan Wang, Aijing Wang, Yuanhong Xu, Jilu Shen, Ziyong Sun, Z.-J. Chen, Yizhao Ni, Jinli Sun, Yong-Shuang Chu, Shuo Tian, Zhidong Hu, Jinyan Li, Yu Yang, Jingxia Lin, Bin Shan, Yan Du, Yong Han, Siyao Guo, Lisha Wei, Longtao Wu, Hongfeng Zhang, Jinliang Kong, Yangfan Hu, Xiao Man Ai, Chao Zhuo, Danhong Su, Qing Yang, Bei Jia, Wenxiang Huang · 发表于：Clinical Microbiology and Infection · 年份：2016 · DOI：10.1016/j.cmi.2016.01.001 · 被引用次数：377 · 研究领域：Antibiotic Resistance in Bacteria、Antibiotic Use and Resistance、Urinary Tract Infections Management

With the aim of gathering temporal trends on bacterial epidemiology and resistance from multiple laboratories in China, the CHINET surveillance system was organized in 2005. Antimicrobial susceptibility testing was carried out according to a unified protocol using the Kirby-Bauer method or automated systems. Results were analyzed according to Clinical and Laboratory Standards Institute (CLSI) 2014 definitions. Between 2005 and 2014, the number of bacterial isolates ranged between 22,774 and 84,572 annually. Rates of extended-spectrum β-lactamase production among Escherichia coli isolates were stable, between 51.7 and 55.8%. Resistance of E. coli and Klebsiella pneumoniae to amikacin, ciprofloxacin, piperacillin/tazobactam and cefoperazone/sulbactam decreased with time. Carbapenem resistance among K. pneumoniae isolates increased from 2.4 to 13.4%. Resistance of Pseudomonas aeruginosa strains against all of antimicrobial agents tested including imipenem and meropenem decreased with time. On the contrary, resistance of Acinetobacter baumannii strains to carbapenems increased from 31 to 66.7%. A marked decrease of methicillin resistance from 69% in 2005 to 44.6% in 2014 was observed for Staphylococcus aureus. Carbapenem resistance rates in K. pneumoniae and A. baumannii in China are high. Our results indicate the importance of bacterial surveillance studies.