Prp19 facilitates invasion of hepatocellular carcinoma via p38 mitogen-activated protein kinase/Twist1 pathway

作者：Jie Yin, Lan Wang, Ji‐Min Zhu, Qian Yu, Ruyi Xue, Ying Fang, Yian Zhang, Yanjie Chen, Taotao Liu, Ling Dong, Xizhong Shen · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.7877 · 被引用次数：27 · 研究领域：RNA modifications and cancer、RNA Research and Splicing、Ubiquitin and proteasome pathways

// Jie Yin 1, * , Lan Wang 2, * , Ji-Min Zhu 1 , Qian Yu 1 , Ru-Yi Xue 1 , Ying Fang 1 , Yi-An Zhang 1 , Yan-Jie Chen 1 , Tao-Tao Liu 1 , Ling Dong 1 , Xi-Zhong Shen 1, 3, 4 1 Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China 2 Department of Biochemistry and Molecular Biology, Shanghai Medical College of Fudan University, Shanghai, China 3 Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai, China 4 Key Laboratory of Medical Molecular Virology, Shanghai Medical College of Fudan University, Shanghai, China * These authors have contributed equally to this work Correspondence to: Xi-Zhong Shen, e-mail: shen.xizhong@zs-hospital.sh.cn Ling Dong, e-mail: dong.ling@zs-hospital.sh.cn Keywords: liver cancer, tumor progression, ubiquitination, signaling pathway Received: July 10, 2015     Accepted: February 20, 2016     Published: March 03, 2016 ABSTRACT Pre-mRNA processing factor 19 (Prp19) is involved in many cellular events including pre-mRNA processing and DNA damage response. However, the pathological role of Prp19 in hepatocellular carcinoma (HCC) is still elusive. Here, we reported that Prp19 was increased in most HCC tissues and HCC cell lines, and its overexpression in HCC tissues was positively correlated with vascular invasion, tumor capsule breakthrough and poor prognosis. Prp19 potentiated migratory and invasive abilities of HCC cells in vitro and in vivo . Furt...