HSPA8/HSC70 chaperone protein

作者：François Stricher, Christophe F. Macri, Marc Ruff, Sylviane Muller · 发表于：Autophagy · 年份：2013 · DOI：10.4161/auto.26448 · 被引用次数：455 · 研究领域：Heat shock proteins research、Endoplasmic Reticulum Stress and Disease、Autophagy in Disease and Therapy

HSPA8/HSC70 protein is a fascinating chaperone protein. It represents a constitutively expressed, cognate protein of the HSP70 family, which is central in many cellular processes. In particular, its regulatory role in autophagy is decisive. We focused this review on HSC70 structure-function considerations and based on this, we put a particular emphasis on HSC70 targeting by small molecules and peptides in order to develop intervention strategies that deviate some of HSC70 properties for therapeutic purposes. Generating active biomolecules regulating autophagy via its effect on HSC70 can effectively be designed only if we understand the fine relationships between HSC70 structure and functions.