Evaluating the Microcirculation of Normal Extraocular Muscles Using Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging

作者：Guo Yu, Lei Huo, Penghui Wang, Lixiang Huang, Chao Chai, Fengyuan Sun, Shuang Xia, Wen Shen · 发表于：Journal of Computer Assisted Tomography · 年份：2016 · DOI：10.1097/rct.0000000000000388 · 被引用次数：3 · 研究领域：Ophthalmology and Eye Disorders、Vestibular and auditory disorders、Advanced Neuroimaging Techniques and Applications

PURPOSE: The purpose of this work was to evaluate the microcirculation of normal extraocular muscles using quantitative dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) (DCE-MRI). MATERIALS AND METHODS: The institutional review board approved the study. Forty-eight eyes were examined using quantitative DCE-MRI on a 3-T MRI system. Quantitative parameters, including the volume transfer constant (Ktrans), the fractional volume of extravascular extracellular space (Ve), and the rate constant (Kep) of each extraocular muscles, were analyzed. The type of DEC time-intensity curve (TIC) was evaluated. The parameters of bilateral extraocular muscles were compared using the Wilcoxon test. The difference in quantitative values of different extraocular muscles was compared using independent-samples Kruskal-Wallis test. RESULTS: No statistical differences of parameters were found between the left and right extraocular muscles (P > 0.05). Volume transfer constant values in medial rectus (MR) muscles and inferior rectus (IR) muscles were significantly higher than those in the lateral rectus (LR) muscles and superior rectus (SR) muscles (P < 0.05). The median Ktrans value of the MR (0.170) was higher than that of the IR (0.151); however, the difference was not significant (P > 0.05). In the 4 extraocular muscles, the Ve values of MR are the largest, followed by the IR, LR, and SR values. The DCE time-intensity curves of extraocular muscles are type II or type III. Medial rec...