Sleep Duration and Subsequent Cortical Thinning in Cognitively Normal Older Adults

作者：Adam P. Spira, Christopher E. Gonzalez, Vijay K. Venkatraman, Mark N. Wu, Jennifer L. Pacheco, Eleanor Marie Simonsick, Luigi Ferrucci, Susan M. Resnick · 发表于：SLEEP · 年份：2016 · DOI：10.5665/sleep.5768 · 被引用次数：172 · 研究领域：Sleep and related disorders、Sleep and Work-Related Fatigue、Obstructive Sleep Apnea Research

STUDY OBJECTIVES: To determine the association between self-reported sleep duration and cortical thinning among older adults. METHODS: We studied 122 cognitively normal participants in the Baltimore Longitudinal Study of Aging with a mean age = 66.6 y (range, 51-84) at baseline sleep assessment and 69.5 y (range, 56-86) at initial magnetic resonance imaging (MRI) scan. Participants reported average sleep duration and completed a mean of 7.6 1.5-T MRI scans (range, 3-11), with mean follow-up from initial scan of 8.0 y (range, 2.0-11.8). RESULTS: In analyses adjusted for age, sex, education, race, and interval between sleep assessment and initial MRI scan, participants reporting > 7 h sleep at baseline had thinner cortex in the inferior occipital gyrus and sulcus of the left hemisphere at initial MRI scan than those reporting 7 h (cluster P < 0.05). In adjusted longitudinal analyses, compared to those reporting 7 h of sleep, participants reporting < 7 h exhibited higher rates of subsequent thinning in the superior temporal sulcus and gyrus, inferior and middle frontal gyrus, and superior frontal sulcus of the left hemisphere, and in the superior frontal gyrus of the right hemisphere; those reporting > 7 h of sleep had higher rates of thinning in the superior frontal and middle frontal gyrus of the left hemisphere (cluster P < 0.05 for all). In sensitivity analyses, adjustment for apolipoprotein E (APOE) e4 genotype reduced or eliminated some effects but revealed others. When re...