Cypate‐Conjugated Porous Upconversion Nanocomposites for Programmed Delivery of Heat Shock Protein 70 Small Interfering RNA for Gene Silencing and Photothermal Ablation

作者：Lu Wang, Chang Gao, Keyin Liu, Yuxin Liu, Liyi Ma, Lidong Liu, Xiaoxia Du, Jing Zhou · 发表于：Advanced Functional Materials · 年份：2016 · DOI：10.1002/adfm.201600035 · 被引用次数：103 · 研究领域：Nanoplatforms for cancer theranostics、Luminescence Properties of Advanced Materials、Luminescence and Fluorescent Materials

Synergistic therapy is an accepted method of enhancing the efficacy of cancer therapies. In this study, cypate‐conjugated porous NaLuF4 doped with Yb3+, Er3+, and Gd3+ is synthesized and its potential for upconversion luminescence/magnetic resonance dual‐modality molecular imaging for guiding oncotherapy is tested. Loading cypate‐conjugated upconversion nanoparticles (UCNP‐cy) with small interfering RNA gene against heat shock protein 70 (UCNP‐cy‐siRNA) enhances the cell damage. UCNP‐cy‐siRNA exhibits remarkable antitumor efficacy in vivo as a result of the synergistic effects of gene silencing and photothermal therapy, with low drug dose and minimal side effects. This result thus provides an explicit strategy for developing next‐generation multifunctional nanoplatforms for multimodal imaging‐guided synergistic oncotherapy.