Elevated expression of HIF-lα in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia

作者：Fei Wu, Sentai Ding, Xin Li, Hui Wang, Shuai Liu, Haihu Wu, Dongbin Bi, Kejia Ding, Jiajü Lü · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.7641 · 被引用次数：16 · 研究领域：Cancer, Hypoxia, and Metabolism、Prostate Cancer Treatment and Research、Prostate Cancer Diagnosis and Treatment

// Fei Wu 1,2,* , Sentai Ding 1,* , Xin Li 1 , Hui Wang 3 , Shuai Liu 1 , Haihu Wu 1 , Dongbin Bi 1 , Kejia Ding 1 and Jiaju Lu 1 1 Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China 2 Department of Urology, Huashan Hospital, Fudan University, Shanghai, China 3 Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China * These authors have contributed equally to this work Correspondence to: Jiaju Lu, email: // Keywords : benign prostatic hyperplasia(BPH), hypoxia inducible factor-1alpha(HIF-lα), acute urine retention(AUR), fetal prostate(FP), Pathology Section Received : September 23, 2015 Accepted : January 31, 2016 Published : February 23, 2016 Abstract Background: Benign prostatic hyperplasia (BPH) is one of the most common diseases in middle-age or older men. Increasing evidence has shown that BPH is associated with hypoxia microenvironment. Methods: We retrospectively collected patient data and tissue samples from fetal prostates(FP), normal prostates(NP), intra-acinar of BPH, peri-acinar of BPH, prostate cancers and sarcomas of prostate. The expression of HIF-1α, as well as VEGF was visualized by immunohistochemistry and statistically analyzed with clinical parameters. Results: Expression of HIF-lα was observed in intra-acinar of BPH (69.5%), prostate cancer (85.7%) and all FPs, while NP and peri-acinar of BPH tissues were all stained negative. HIF-lα leve...