Electroacupuncture decreases the progression of ovarian hyperstimulation syndrome in a rat model

作者：Li Chen, Haixiang Sun, Youbing Xia, Liucai Sui, Ji Zhou, Xuan Huang, Jingwei Zhou, Yi-Dan Shao, Tao Shen, Qin Sun, Yuanjiao Liang, Bing Yao · 发表于：Reproductive BioMedicine Online · 年份：2016 · DOI：10.1016/j.rbmo.2016.02.006 · 被引用次数：14 · 研究领域：Acupuncture Treatment Research Studies、Phytochemical and Pharmacological Studies、Complementary and Alternative Medicine Studies

This study aimed to elucidate the effect of electroacupuncture treatment on preventing early ovarian hyperstimulation syndrome (OHSS) and the potential mechanisms involved using an induced rat model. The ovarian response was examined by measuring ovary weight, vascular permeability, levels of inflammation (interleukin-6), tumour necrosis factor alpha, chemokine ligand 2 (also known as monocyte chemoactic protein 1), vascular endothelial growth factor and hormone concentrations (oestradiol, progesterone, testosterone and prolactin). Sprague-Dawley female rats underwent ovarian stimulation to induce OHSS. Hyperstimulated rats received consecutive electroacupuncture treatment from 3 days before the beginning of pregnant mare serum gonadotrophin treatment or the time point of pregnant mare serum gonadotrophin treatment respectively, and last until 3 days after HCG administration. Electroacupuncture treatment reduced ovary weight and vascular permeability in hyperstimulated rats. Electroacupuncture treatment also reduced the levels of serum steroid hormones (progesterone and testosterone), inflammatory cytokines (interleukin-6, tumour necrosis factor alpha and monocyte chemotactic protein 1 and vascular endothelial growth factor in hyperstimulated rats. The results indicate that electroacupuncture can modulate endocrine hormone secretion and affect the secretion of inflammatory cytokines and vascular endothelial growth factor, and thus prevent the progress of OHSS. Electroacupunct...