A simple practice guide for dose conversion between animals and human

作者：Anroop B. Nair, Shery Jacob · 发表于：Journal of Basic and Clinical Pharmacy · 年份：2016 · DOI：10.4103/0976-0105.177703 · 被引用次数：6140 · 研究领域：Animal testing and alternatives、Computational Drug Discovery Methods、Pharmaceutical and Antibiotic Environmental Impacts

Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associated with animal weight while extrapolating the doses of therapeutic agents among the species. This review provides basic information about translation of doses between species and estimation of starting dose for clinical trials using allometric scaling. The method of calculation of injection volume for parenteral formulation based on human equivalent dose is also briefed.