Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8)

作者：Zhongsheng Zang, Yan‐Ming Xu, Andy T. Y. Lau · 发表于：Toxicology Research · 年份：2016 · DOI：10.1039/c5tx00424a · 被引用次数：47 · 研究领域：Trace Elements in Health、Drug Transport and Resistance Mechanisms、Heavy Metal Exposure and Toxicity

influx mediated by ZIP8 can lead to the pathogenesis of osteoarthritis and inflammatory diseases. ZIP8 also mediates the cellular uptake of divalent metal ions including iron, manganese, and the toxic heavy metal cadmium. Individuals with SLC39A8 mutations and transgenic mouse models are starting to reveal the critical role that this gene plays in embryonic development and the metabolism of essential metal ions. Here we summarize our current understanding of ZIP8's function and regulation, at both the molecular and biological levels. We also review the association of ZIP8 with various diseases and its linkage with complex disorders like obesity, hypertension, and schizophrenia as revealed by several large genome-wide association studies.