Comparison of multiple quantitative MRI parameters for characterization of the goat cartilage in an ongoing osteoarthritis: dGEMRIC, T1ρ and sodium

作者：Joachim H. X. Schrauth, Gunthard Lykowsky, Kathrin Hemberger, Jakob Kreutner, Daniel L. Weber, Lars Rackwitz, Ulrich Nöth, Peter M. Jakob, Daniel Haddad · 发表于：Zeitschrift für Medizinische Physik · 年份：2015 · DOI：10.1016/j.zemedi.2015.11.004 · 被引用次数：4 · 研究领域：Osteoarthritis Treatment and Mechanisms、Advanced MRI Techniques and Applications、Bone and Joint Diseases

Osteoarthritis (OA) is a degenerative joint disease leading to cartilage deterioration by loss of matrix, fibrillation, formation of fissures, and ultimately complete loss of the cartilage surface. Here, three magnetic resonance imaging (MRI) techniques, dGEMRIC (delayed Gadolinium enhanced MRI of cartilage; dG1=T1,post; dG2=1/T1,post-1/T1,pre), T1ρ,and sodium MRI, are compared in a preclinical in vivo study to evaluate the differences in their potential for cartilage characterization and to establish an examination protocol for a following clinical study. OA was induced in 12 caprine knees (6 control, 6 therapy). Adipose derived stem cells were injected afterwards as a treatment. The animals were examined healthy, 3 and 16 weeks postoperatively with all three MRI methods. Using statistical analysis, the OA development and the degree of correlation between the different MRI methods were determined. A strong correlation was observed between the dGEMRIC indices dG1 and dG2 (r=–0.87) which differ only in considering or not considering the T1 baseline. Moderate correlations were found between T1ρ and dG1 (r=0.55), T1ρ and dG2 (r=0.47) and at last, sodium and dG1 (r=0.45). The correlations found in this study match to the biomarkers which the methods are sensitive to. Even though the goat cartilage is significantly thinner than the human cartilage and even more in a degenerated cartilage, all three methods were able to characterize the cartilage over the whole period of time durin...