Emerging malnutrition during hospitalisation independently predicts poor 3-month outcomes after acute stroke: data from a Chinese cohort.

作者：Jing Zhang, Xingquan Zhao, Anxin Wang, Yong Zhou, Bo Yang, Na Wei, Dandan Yu, Jingjing Lu, Shengyun Chen, Yilong Wang, Chunxue Wang, Rong Xue, Yanqiu Zhang, Yansheng Li, Ling Hong Yu, Shaoshi Wang, Zhenli Chen, Tianheng Zheng, Zhuo Zhang, Xia Meng, Maolin He, Wei Li, Zhaohui Zhang, Fei Zeng, Shengdi Chen, Yi Fu, Guidong Liu, Lijuan Wang, Zhiheng Huang, Jianguo Ma, Mu Fengqun, Yun Xu, Rong Huang, Lin Wang, Yongjun Wang · 发表于：PubMed · 年份：2015 · DOI：10.6133/apjcn.2015.24.3.13 · 被引用次数：39 · 研究领域：Nutrition and Health in Aging、Dysphagia Assessment and Management、Frailty in Older Adults

OBJECTIVE: Questions exist regarding the causal relationship between malnutrition and stroke outcomes. This study aimed to determine whether nutritional status changes or malnutrition during hospitalisation could predict 3-month outcomes in acute stroke patients. METHODS: During a 10-month period, patients who suffered their first stroke within 7 days after stroke onset were included in this prospective multi-centre study. The demographic parameters, stroke risk and severity factors, malnutrition risk factors and dysphagia were recorded. Nutritional status was assessed by 3 anthropometric and 3 biochemical indices. Changes in nutritional status were defined by comparing the admission values with the 2-week values. A Modified Rankin Scale score of 3-6 was defined as a poor outcome at the 3-month follow-up. Univariate and multiple logistic regression analyses were used to investigate the power of nutritional status changes in predicting poor patient outcomes. RESULTS: Data from 760 patients were analysed. Poor outcomes were observed in 264 (34.7%) patients. Malnutrition prevalence was 3.8% at admission and 7.5% after 2-weeks in hospital, which could not predict 3-month outcome. Emerging malnutrition was observed in 36 patients (4.7%) during the 2-week hospitalisation period and independently predicted poor 3-month outcomes after adjusting for confounding factors (odds ratio 1.37, 95% confidence interval 1.03-1.83). CONCLUSIONS: Emerging malnutrition during hospitalisation indep...