GOLPH3 is a potential therapeutic target and a prognostic indicatior of poor survival in bladder cancer treated by cystectomy

作者：Qing Zhang, Junlong Zhuang, Yongming Deng, Xiaozhi Zhao, Bo Tang, Dongwei Yao, Wei Zhao, Cunjie Chang, Qun Lu, Wei Chen, Shiwei Zhang, Changwei Ji, Lin Cao, Hongqian Guo · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.4867 · 被引用次数：23 · 研究领域：Cancer, Lipids, and Metabolism、Ferroptosis and cancer prognosis、PI3K/AKT/mTOR signaling in cancer

// Qing Zhang 1, * , Junlong Zhuang 1, * , Yongming Deng 1, * , Xiaozhi Zhao 1 , Bo Tang 3 , Dongwei Yao 1 , Wei Zhao 4 , Cunjie Chang 4 , Qun Lu 1 , Wei Chen 1 , Shiwei Zhang 1 , Changwei Ji 1 , Lin Cao 2, 3 , Hongqian Guo 1 1 Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, Jiangsu, PR China 2 College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China 3 Vazyme Biotech Co., Ltd, Nanjing 210000, Jiangsu, PR China 4 MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, Jiangsu 210061, China * These authors have contributed equally to this work Correspondence to: Hongqian Guo, e-mail: dr.guohongqian@gmail.com Keywords: bladder cancer, GOLPH3, AKT/mTOR signalling, prognosis, survival Received: March 16, 2015      Accepted: August 12, 2015      Published: August 22, 2015 ABSTRACT Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. However, its clinical significance and biological role in bladder cancer remains unclear. In this study, we sought to analyze the GOLPH3 expression in bladder cancer samples and cells, and explore its clinical significance and biological role. We found that GOLPH3 was significantly increased in bladder cancer tissu...