CD226 reduces endothelial cell glucose uptake under hyperglycemic conditions with inflammation in type 2 diabetes mellitus

作者：Yuan Zhang, Tian Liu, Yu Chen, Zilong Dong, Jinxue Zhang, Yizheng Sun, Boquan Jin, Feng Gao, Shuzhong Guo, Ran Zhuang · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.7505 · 被引用次数：14 · 研究领域：Immune Cell Function and Interaction、Adipokines, Inflammation, and Metabolic Diseases、Immune cells in cancer

// Yuan Zhang 1,* , Tian Liu 2,* , Yu Chen 3,* , Zilong Dong 4 , Jinxue Zhang 5 , Yizheng Sun 1 , Boquan Jin 5 , Feng Gao 1 , Shuzhong Guo 2 and Ran Zhuang 5 1 Department of Aerospace Medicine, Fourth Military Medical University, Xi’an, China 2 Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China 3 Department of Gastroenterology, Xijing Hospital, Fourth Military Medical University, Xi’an, China 4 Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China 5 Department of Immunology, Fourth Military Medical University Xi’an, China * These authors have contributed equally to this work Correspondence to: Ran Zhuang, email: // Keywords : CD226, high fat diet, type 2 diabetes mellitus, endothelial cells, Pathology Section Received : May 13, 2015 Accepted : January 26, 2016 Published : February 19, 2016 Abstract CD226 is a co-stimulatory adhesion molecule found on immune and endothelial cells. Here, we evaluated a possible role for CD226 in inhibiting glucose uptake in isolated human umbilical vein endothelial cells (HUVECs) and in wild-type (WT) and CD226 knockout (KO) mice with high-fat diet (HFD)-induced type 2 diabetes (T2DM). CD226 expression increased under hyperglycemic conditions in the presence of TNF-α. Furthermore, CD226 knockdown improved glucose uptake in endothelial cells, and CD226 KO mice exhibited increased glucose tolerance. Levels of soluble CD226 in p...