Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

作者：Konrad R. Gabrusiewicz, Benjamin A.T. Rodriguez, Jun Wei, Yuuri Hashimoto, Luke M. Healy, Sourindra N. Maiti, Ginu A. Thomas, Shouhao Zhou, Qianghu Wang, Ahmed Elakkad, Brandon D. Liebelt, Nasser K. Yaghi, Ravesanker Ezhilarasan, Neal Huang, Jeffrey S. Weinberg, Sujit S. Prabhu, Ganesh Rao, Raymond A. Sawaya, Lauren A. Langford, Janet M. Bruner, Gregory N. Fuller, Amit Bar‐Or, Wei Li, Rivka R. Colen, Michael A. Curran, Krishna Bhat, Jack Perry Antel, Laurence J.N. Cooper, Erik P. Sulman, Amy B. Heimberger · 发表于：JCI Insight · 年份：2016 · DOI：10.1172/jci.insight.85841 · 被引用次数：465 · 研究领域：Immune cells in cancer、Neuroinflammation and Neurodegeneration Mechanisms、MicroRNA in disease regulation

cells, microglia and MDSCs constituted a higher percentage of GAMs than did macrophages. GAM profiling using flow cytometry studies revealed a continuum between the M1- and M2-like phenotype. Contrary to current dogma, GAMs exhibited distinct immunological functions, with the former aligned close to nonpolarized M0 macrophages.