Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway

作者：Li Xu, Huan Ning, Ling Gu, Qinghong Wang, Wenbao Lu, Hui Peng, Weiguang Cui, Baoling Ying, Christina R. Ross, Gerald M. Wilson, Lin Wei, William S.M. Wold, Jianguo Liu · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.6149 · 被引用次数：34 · 研究领域：RNA Research and Splicing、Molecular Biology Techniques and Applications、Cancer-related molecular mechanisms research

// Li Xu 1,2,* , Huan Ning 2,* , Ling Gu 2 , Qinghong Wang 2 , Wenbao Lu 2 , Hui Peng 2 , Weiguang Cui 2 , Baoling Ying 3 , Christina R. Ross 4 , Gerald M. Wilson 4 , Lin Wei 5 , William S.M. Wold 3 and Jianguo Liu 2 1 Department of Respiratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2 Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA 3 Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO, USA 4 Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA 5 Department of Immunology, School of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei, China * These authors have contributed equally to the work Correspondence to: Jianguo Liu, email: // Keywords : breast cancer, tristetraprolin, cell cycle, AP-1, apoptosis Received : July 08, 2015 Accepted : September 30, 2015 Published : October 19, 2015 Abstract The main characteristic of cancers, including breast cancer, is the ability of cancer cells to proliferate uncontrollably.  However, the underlying mechanisms of cancer cell proliferation, especially those regulated by the RNA binding protein tristetraprolin (TTP), are not completely understood. In this study, we found that TTP inhibits cell proliferation in vitro and suppresses tumor growth in vivo throug...