Acute effects of breaking up prolonged sitting on fatigue and cognition: a pilot study

作者：Patrik Wennberg, Carl‐Johan Boraxbekk, Michael J. Wheeler, Bethany Howard, Paddy C. Dempsey, Gavin Lambert, Nina Eikelis, Robyn N. Larsen, Parneet Sethi, Jessica Occleston, Jenny Hernestål-Boman, Kathryn A. Ellis, Neville Owen, David W. Dunstan · 发表于：BMJ Open · 年份：2016 · DOI：10.1136/bmjopen-2015-009630 · 被引用次数：192 · 研究领域：Physical Activity and Health、Sleep and Work-Related Fatigue、Sleep and related disorders

OBJECTIVES: To compare the acute effects of uninterrupted sitting with sitting interrupted by brief bouts of light-intensity walking on self-reported fatigue, cognition, neuroendocrine biomarkers and cardiometabolic risk markers in overweight/obese adults. DESIGN: Randomised two-condition crossover trial. SETTING: Laboratory study conducted in Melbourne, Australia. PARTICIPANTS: 19 overweight/obese adults (45-75 years). INTERVENTIONS: After an initial 2 h period seated, participants consumed a meal-replacement beverage and completed (on 2 days separated by a 6-day washout period) each condition over the next 5 h: uninterrupted sitting (sedentary condition) or sitting with 3 min bouts of light-intensity walking every 30 min (active condition). PRIMARY OUTCOME MEASURES: Self-reported fatigue, executive function and episodic memory at 0 h, 4 h and 7 h. SECONDARY OUTCOME MEASURES: Neuroendocrine biomarkers and cardiometabolic risk markers (blood collections at 0 h, 4 h and 7 h, blood pressure and heart rate measured hourly and interstitial glucose measured using a continuous glucose monitoring system). RESULTS: During the active condition, fatigue levels were lower at 4 h (-13.32 (95% CI -23.48 to -3.16)) and at 7 h (-10.73 (95% CI -20.89 to -0.58)) compared to the sedentary condition. Heart rate was higher at 4 h (4.47 (95% CI 8.37 to 0.58)) and at 7 h (4.32 (95% CI 8.21 to 0.42)) during the active condition compared to the sedentary condition. There were no significant differen...