Wait-and-see or radical surgery for rectal cancer patients with a clinical complete response after neoadjuvant chemoradiotherapy: a cohort study

作者：Jun Li, Hao Liu, Jie Yin, Sai Liu, Junjie Hu, Feng Du, Jiatian Yuan, Bo Lv, Jun Fan, Shusheng Leng, Xin Zhang · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.6093 · 被引用次数：85 · 研究领域：Colorectal Cancer Surgical Treatments、Colorectal and Anal Carcinomas、Gastric Cancer Management and Outcomes

// Jun Li 1 , Hao Liu 2 , Jie Yin 3 , Sai Liu 4 , Junjie Hu 5 , Feng Du 6 , Jiatian Yuan 1 , Bo Lv 1 , Jun Fan 1 , Shusheng Leng 1 and Xin Zhang 1 1 General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, People’s Republic of China 2 2nd Affiliated Hospital of Jilin University, Changchun, People’s Republic of China 3 Xuzhou Central Hospital, Xuzhou, People’s Republic of China 4 Beijing Youan Hospital, Capital Medical University, Beijing, People’s Republic of China 5 Hubei Cancer Hospital, Wuhan, People’s Republic of China 6 Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, People’s Republic of China Correspondence to: Jun Li, email: // Keywords : rectal cancer, neoadjuvant chemoradiotherapy, complete clinical response Received : July 31, 2015 Accepted : September 24, 2015 Published : October 12, 2015 Abstract A wait-and-see policy might be considered instead of surgery for rectal cancer patients with no residual tumor or involved lymph nodes on imaging or endoscopy after neoadjuvant chemoradiotherapy (clinical complete response, cCR). In this cohort study, we compared the oncologic outcomes of rectal cancer patients with a cCR who were managed according to a wait-and-see policy (observation group) or with surgery (surgery group). In the observation group, follow-up was performed every 3 months for the first year and consisted of MRI, endoscopy wi...