Promoting Effect of Bile Acids on Colon Carcinogenesis After Intrarectal Instillation of N -Methyl- N ′ nitro- N -nitrosoguanidine in Rats 2

作者：Tomio Narisawa, Napoleon E. Magadia, John H. Weisburger, Ernst L. Wynder · 发表于：JNCI Journal of the National Cancer Institute · 年份：1974 · DOI：10.1093/jnci/53.4.1093 · 被引用次数：705 · 研究领域：Drug Transport and Resistance Mechanisms、Cholangiocarcinoma and Gallbladder Cancer Studies、Helicobacter pylori-related gastroenterology studies

The effect of 2 bile acids in colon carcinogenesis was studied in rats. A single dose of N-methyl-N′nitro- N-nitrosoguanidine (MNNG) was instilled intrarectally. Subsequently, repeated intrarectal doses of lithocholic or taurodeoxycholic acid were administered. Both bile acids increased the frequency of MNNG-induced colorectal neoplasms. Neither bile acid induced tumors when used alone. The lesions were like those induced by MNNG alone and included adenomas and adenocarcinomas. The bile acids acted as promoters of carcinogenesis.