The prognostic value of pretreatment CA-125 levels and CA-125 normalization in ovarian clear cell carcinoma: a two-academic-institute study

作者：Huimin Bai, Guisha Sha, Meizhu Xiao, Huiqiao Gao, Dongyan Cao, Jiaxin Yang, Jie Chen, Yue Wang, Zhenyu Zhang, Keng Shen · 发表于：Oncotarget · 年份：2016 · DOI：10.18632/oncotarget.7216 · 被引用次数：31 · 研究领域：Ovarian cancer diagnosis and treatment、Endometrial and Cervical Cancer Treatments、Intraperitoneal and Appendiceal Malignancies

// Huimin Bai 1, 2 , Guisha Sha 2 , Meizhu Xiao 1 , Huiqiao Gao 1 , Dongyan Cao 2 , Jiaxin Yang 2 , Jie Chen 3 , Yue Wang 4 , Zhenyu Zhang 1 , Keng Shen 2 1 Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China 2 Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China 3 Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China 4 Department of Pathology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China Correspondence to: Zhenyu Zhang, e-mail: zhenyuzhang2000@163.com Keng Shen, e-mail: skpumch@126.com , shenkeng@vip.sina.com Keywords: clear cell carcinoma, ovary, CA-125, pretreatment, normalization Received: October 29, 2015     Accepted: January 28, 2016     Published: February 06, 2016 ABSTRACT Objectives: The present study investigated the clinical implications of pretreatment carbohydrate antigen 125 (CA-125) levels and CA-125 normalization in patients with ovarian clear cell carcinoma (CCC), and it provides useful information for the improvement of monitoring strategies for this lethal disease. Methods: The medical records of patients with ovarian CCC who had undergone primary staging surgery or cytoreductive surgery followed by systemic chemotherapy were...