LIPOPROTEINS AS MEDIATORS FOR THE EFFECTS OF ALCOHOL CONSUMPTION AND CIGARETTE SMOKING ON CARDIOVASCULAR MORTALITY: RESULTS FROM THE LIPID RESEARCH CLINICS FOLLOW-UP STUDY

作者：Michael H. Criqui, Linda D. Cowan, Herman A. Tyroler, Shrikant I. Bangdiwala, Gerardo M HEISS, Robert B. Wallace, Richard D. Cohn · 发表于：American Journal of Epidemiology · 年份：1987 · DOI：10.1093/oxfordjournals.aje.a114702 · 被引用次数：287 · 研究领域：Cancer, Lipids, and Metabolism、Lipoproteins and Cardiovascular Health、Diabetes, Cardiovascular Risks, and Lipoproteins

Criqui, M. H. (Dept of Community and Family Medicine, U. of California, San Diego, La Jolla, CA 92093), L. D. Cowan, H. A. Tyroler, S. Bangdiwala, Q. Heiss, R. B. Wallace, and R. Conn. Upoproteins as mediators for the effects of alcohol consumption and cigarette smoking on cardiovascular mortality: results from the Upid Research Clinics Follow-up Study. Am J Epidemiol 1987; 126:629–37. Because alcohol consumption is associated with increased high density lipoprotein (HDL) cholesterol and decreased low density lipoprotein (LDL) cholesterol, and cigarette smoking is associated with lower HDL cholesterol and higher LDL cholesterol, there has been speculation that the protective effect of moderate alcohol consumption and/or the noxious effect of cigarette smoking for cardiovascular disease might be mediated in large part by a lipoprotein mechanism. The authors examined this question in a prospective study of 7,481 men and women in 10 North American populations initially seen in 1972–1976 and followed for an average of 8.5 years. Moderate alcohol consumption was weakly protective for cardiovascular disease, while cigarette smoking was strongly and significantly associated with cardiovascular disease mortality. As expected, LDL cholesterol was positively related and HDL cholesterol was inversely related to cardiovascular disease mortalIty. However, multivarlable analysis of cardiovascular disease mortality alternately excluding and including HDL cholesterol and LDL cholesterol as c...