Synthesis and biological activity of a new frog skin peptide, ranamargarin.

作者：Yang Lü, Jianqiu Peng, Yuewen Zhu, S X Wu, Yi Tang, Shao‐Fang Tian, G Zou · 发表于：PubMed · 年份：1990 · 被引用次数：2 · 研究领域：Antimicrobial Peptides and Activities、Chemical Synthesis and Analysis、Neuropeptides and Animal Physiology

A new frog skin peptide, ranamargarin depicted as H-Asp-Asp-Ala-Ser-Asp-Arg-Ala-Lys-Lys-Phe-Tyr-Gly-Leu-Met-NH2' was synthesized by the conventional method. Comparisons of chemical and biological properties of both the synthetic and natural ranamargarins indicated that they were identical, so the chemical structure of ranamargarin was confirmed. Preliminary pharmacological study showed that ranamargarin was highly selective towards the SP-P subtype receptor.