Carbapenem resistance: overview of the problem and future perspectives

作者：Georgios Meletis · 发表于：Therapeutic Advances in Infectious Disease · 年份：2015 · DOI：10.1177/2049936115621709 · 被引用次数：729 · 研究领域：Antibiotic Resistance in Bacteria、Antibiotics Pharmacokinetics and Efficacy、Vibrio bacteria research studies

Carbapenem resistance, mainly among Gram-negative pathogens, is an ongoing public-health problem of global dimensions. This type of antimicrobial resistance, especially when mediated by transferable carbapenemase-encoding genes, is spreading rapidly causing serious outbreaks and dramatically limiting treatment options. In this article, important key points related to carbapenem resistance are reviewed and future perspectives are discussed.