Treatable traits: toward precision medicine of chronic airway diseases

作者：Àlvar Agustí, Elisabeth H. Bel, Mike Thomas, Claus Vogelmeier, Guy Brusselle, Stephen T. Holgate, Marc Humbert, Paul Jones, Peter G. Gibson, Jørgen Vestbo, Richard Beasley, Ian Pavord · 发表于：European Respiratory Journal · 年份：2016 · DOI：10.1183/13993003.01359-2015 · 被引用次数：1082 · 研究领域：Asthma and respiratory diseases、Respiratory and Cough-Related Research、Chronic Obstructive Pulmonary Disease (COPD) Research

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms (i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed (i.e. phenotypes) which require individualised treatment. Precision medicine is defined as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations". In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular.