SUBDETERMINANTS d AND y OF HEPATITIS B ANTIGEN AS EPIDEMIOLOGIC MARKERS 1

作者：James W. Mosley, Virginia M. Edwards, John E. Meihaus, Allan G. Redeker · 发表于：American Journal of Epidemiology · 年份：1972 · DOI：10.1093/oxfordjournals.aje.a121421 · 被引用次数：51 · 研究领域：Hepatitis B Virus Studies、Hepatitis C virus research、Hepatitis Viruses Studies and Epidemiology

Mosley, J. W. (John Wesley Hospital, 2826 S. Hope St., Los Angeles, Calif. 90007), V. M. Edwards, J. E. Meihaus and A. G. Redeker. Sub-determinants d and y of hepatitis B antigen as epidemiologic markers. Am J Epidemiol 95: 529–535, 1972.—A simple Ouchterlony technique for the mutually exclusive d and y subdeterminants of hepatitis B antigen has been applied to selected specimens to investigate whether these antigenic subtypes are derived from the host or the strains of virus. Four y+ infections produced y+ disease in seven genetically related household contacts; likewise, three d+ and 13 y+ index cases gave rise to the consistent subtype in 16 secondary cases among genetically unrelated persons. Further, in a hemodialysis unit in which intra-unit transmission rather than transfusion was suspected as a source of hepatitis B antigen-positive cases, y+ infections were observed in all 23 dialysis patients, all 13 medical-paramedical persons, and all 5 household contacts with specimens available for typing. This result differed significantly from the frequency of y+ infection among other transfused patients (44%) and other medical-paramedical personnel (61%). It is concluded that the d and y subdeterminants are characteristic of the viral strain, and useful as indices of epidemiologic relationship.