Overexpression of DEK is an indicator of poor prognosis in patients with gastric adenocarcinoma

作者：Yingfu Ou, Rongjun Xia, Fanyong Kong, Xiaokang Zhang, Shengjin Yu, Lili Jiang, Linlin Zheng, Lijuan Lin · 发表于：Oncology Letters · 年份：2016 · DOI：10.3892/ol.2016.4147 · 被引用次数：16 · 研究领域：Genetic factors in colorectal cancer、Ovarian cancer diagnosis and treatment、Gastric Cancer Management and Outcomes

Increased expression of the human DEK proto-oncogene (DEK) gene has been associated with numerous human malignancies. The DEK protein is associated with chromatin reconstruction and gene transcription, and is important in cell apoptosis. The present study aimed to elucidate the role of DEK with regard to gastric adenocarcinoma tumor progression and patient prognosis. DEK protein expression was analyzed using immunohistochemistry in 192 tumors paired with adjacent non‑cancerous gastric mucosa that had been surgically resected from patients with primary gastric adenocarcinoma. The association between DEK expression and the clinicopathological characteristics of the patients was evaluated using the χ2 test and Fisher's exact test. The survival rates of the patients were calculated using the Kaplan‑Meier method. Cox analysis evaluated the association between the expression of DEK and the survival rate of the patients. The DEK protein was expressed in 84 patients with gastric adenocarcinoma (43.8%) and in 20 of the paired normal gastric mucosa tissues (11.5%). The DEK expression rate was found to be associated with tumor size (P=0.006), tumor grade (P=0.023), lymph node metastasis (P=0.018), serous invasion (P=0.026), tumor stage (P=0.001) and Ki‑67 expression (P=0.003). Furthermore, patients with gastric adenocarcinoma that expressed DEK had decreased disease‑free (log‑rank, 16.785; P<0.0001) and overall (log‑rank, 15.759; P<0.0001) survival rates compared with patients without D...