Genome-wide analysis of Epstein-Barr virus (EBV) isolated from EBV-associated gastric carcinoma (EBVaGC)

作者：Ying Liu, Wenjun Yang, Yaqi Pan, Jiafu Ji, Zheming Lu, Ke Yang · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.6751 · 被引用次数：50 · 研究领域：Viral-associated cancers and disorders、Lymphoma Diagnosis and Treatment、Cholangiocarcinoma and Gallbladder Cancer Studies

// Ying Liu 1, * , Wenjun Yang 2 , Yaqi Pan 1 , Jiafu Ji 3 , Zheming Lu 1, * , Yang Ke 1 1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Genetics, Peking University Cancer Hospital and Institute, Haidian, Beijing, China 2 Key Laboratory of Reproduction and Heredity of Ningxia Region, Medical Oncology Department of General Hospital, Ningxia Medical University, Yinchuan, Ningxia, China 3 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Haidian, Beijing, China * These authors contributed equally to this work Correspondence to: Zheming Lu, e-mail: zheminglu@163.com Yang Ke, e-mail: keyang@bjmu.edu.cn Keywords: Epstein-Barr virus, gastric carcinoma, EBVaGC, next-generation sequencing Received: July 29, 2015      Accepted: November 26, 2015      Published: December 24, 2015 ABSTRACT Epstein-Barr virus (EBV) is linked to the development of a variety of malignancies, including EBV-associated gastric carcinoma (EBVaGC). In this study, EBVaGC was detected in 15 (7.3%) of 206 GC cases. To identify the EBV genomic variation, EBV genomic sequences isolated from 9 EBVaGC biopsy specimens were successfully retrieved, designated EBVaGC1 to EBVaGC9. By comparative analysis of these strains with another 6 completely sequenced EBV strains, EBV-wild type, B95–8, AG8...