The efficacy of intrauterine injection of human chorionic gonadotropin before embryo transfer in assisted reproductive cycles: Meta-analysis

作者：Hong Ye, Jing Hu, Wencong He, Yong Zhang, Caihong Li · 发表于：Journal of International Medical Research · 年份：2015 · DOI：10.1177/0300060515592903 · 被引用次数：25 · 研究领域：Ovarian function and disorders、Reproductive System and Pregnancy、Ectopic Pregnancy Diagnosis and Management

OBJECTIVES: A systematic review and meta-analysis to evaluate the effect of human chorionic gonadotropin (hCG) intrauterine injection before embryo transfer on the outcome of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). METHODS: Searches of PubMed®, EMBASE®, EBSCO, Web of Science®, SCOPUS® and Cochrane Central Register of Controlled Trials were conducted to retrieve relevant randomized controlled trials (RCTs). Data were extracted and analysed. RESULTS: The meta-analysis included five RCTs (hCG group n = 680; control group n = 707). Intrauterine hCG injection significantly increased rates of biochemical, clinical and ongoing pregnancy compared with controls. There were no between-group differences in implantation or miscarriage rates. CONCLUSION: Women undergoing IVF/ICSI may benefit from intrauterine hCG injection before embryo transfer.