Hepatitis B virus (HBV) receptors: Deficiency in tumor results in scant HBV infection and overexpression in peritumor leads to higher recurrence risk

作者：Ying-Ying Jing, Wen-Ting Liu, Shi-Wei Guo, Fei Ye, Qing-Min Fan, Guo-Feng Yu, Dan-Dan Yu, Lu Gao, Kai Sun, Zhi-Peng Han, Rong Li, Yang Yang, Qiu-Dong Zhao, Meng‐Chao Wu, Hong-Yang Wang, Lixin Wei · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.5518 · 被引用次数：24 · 研究领域：Hepatitis B Virus Studies、Liver Disease Diagnosis and Treatment、Hepatocellular Carcinoma Treatment and Prognosis

// Ying-Ying Jing 1, * , Wen-Ting Liu 1, * , Shi-Wei Guo 1, * , Fei Ye 1 , Qing-Min Fan 1 , Guo-Feng Yu 1 , Dan-Dan Yu 1 , Lu Gao 1 , Kai Sun 1, 2 , Zhi-Peng Han 1 , Rong Li 1 , Yang Yang 1 , Qiu-Dong Zhao 1 , Meng-Chao Wu 1 , Hong-Yang Wang 3 , Li-Xin Wei 1 1 Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China 2 Central Laboratory, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China 3 International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute/Hospital, The Second Military Medical University, Shanghai, China * These authors have contributed equally to this work Correspondence to: Li-Xin Wei, e-mail: weilixin_smmu@163.com Keywords: hepatitis B virus receptor, inflammation, hepatic progenitor cells, recurrence Received: May 26, 2015      Accepted: October 08, 2015      Published: October 20, 2015 ABSTRACT Hepatitis B virus (HBV) infection is a risk factor for hepatocarcinogenesis and recurrence. Here, we sought to characterize intratumoral and peritumoral expression of HBsAg and its specific receptors in HBsAg-positive hepatocellular carcinoma (HCC) patients and further examined their correlation with the recurrence-free survival (RFS). HCC tissue and adjacent normal tissue specimens were acquired from HBsAg-positive patients. The presence of HBsAg and receptors, as well ...