The effective period of preventive antibiotic action in experimental incisions and dermal lesions.

作者：John Frederick Burke · 发表于：PubMed · 年份：1961 · 被引用次数：1285 · 研究领域：Surgical Sutures and Adhesives、Surgical site infection prevention、Nail Diseases and Treatments

There is a definite short period when the developing staphylococcal dermal or incisional infection may be suppressed by antibiotics. This effective period begins the moment bacteria gain access to the tissue is over in 3 hours. Systemic antibiotics have no effect on primary staphylococcal infections if the bacteria creating the infection have been in the tissue longer than 3 hours before the antibiotics are given. Antibiotics cause maximum suppression of infection if given before bacteria gan access to tissue.