12S-hydroxyeicosatetraenoic acid levels link to coronary artery disease in Type 2 diabetic patients.

作者：Hai-Fang Zhang, Changhao Sun, Hong Kuang, Xiaoyan Jiang, H. L. Liu, W. F. Hua, Zhuo Liu, Haiyan Zhou, He Sui, Ruomei Qi · 发表于：PubMed · 年份：2013 · DOI：10.3275/8654 · 被引用次数：19 · 研究领域：Eicosanoids and Hypertension Pharmacology、Fatty Acid Research and Health、Diet, Metabolism, and Disease

BACKGROUND: 12(S)-Hydroxyeicosatetraenoic acid (12(S)-HETE) is a metabolite of arachidonic acid. 12(S)-HETE is involved in the pathogenesis of atherosclerosis and diabetes. However, the correlation between 12(S)-HETE and coronary artery disease (CAD) in the diabetic patient is unclear. AIMS: The study investigated the relationship between 12(S)-HETE and CAD in Type 2 diabetes (T2D). METHODS: Plasma 12(S)- HETE levels were detected by enzyme-linked immunosorbent assay in 103 healthy controls (control), 109 diabetic patients without CAD (diabetic), and 152 diabetic patients with CAD (diabetic-CAD). RESULTS: 12(S)-HETE levels were higher in both diabetic and diabetic-CAD groups compared to control and in the diabetic-CAD group compared to the diabetic group. In the multiple linear stepwise regression analysis, 12(S)-HETE levels correlated independently with CAD, systolic blood pressure, and glycated hemoglobin. CONCLUSIONS: These results indicate that 12(S)-HETE levels are increased in diabetic patients with CAD, suggesting a role for atherosclerosis in T2D.