Knockdown of linc-POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer

作者：Ti‐Dong Shan, Jihao Xu, Tao Yu, Jieyao Li, Linna Zhao, Hui Ouyang, Su Luo, Xi-Ji Lu, Can‐Ze Huang, Qiu-Shen Lan, Wa Zhong, Qi‐Kui Chen · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.5830 · 被引用次数：59 · 研究领域：Cancer, Hypoxia, and Metabolism、Ferroptosis and cancer prognosis、RNA modifications and cancer

// Ti-Dong Shan 1 , Ji-Hao Xu 1 , Tao Yu 1 , Jie-Yao Li 1 , Lin-Na Zhao 3 , Hui Ouyang 1 , Su Luo 1 , Xi-Ji Lu 1 , Can-Ze Huang 1 , Qiu-Shen Lan 2 , Wa Zhong 1 , Qi-Kui Chen 1 1 Department of Gastroenterology and Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, People’s Republic of China 2 Department of General Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, People’s Republic of China 3 Department of Gastroenterology, the First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510504, People’s Republic of China Correspondence to: Tao Yu, e-mail: yutao2014@126.com Qi-Kui Chen, e-mail: qikuichen@yahoo.com Keywords: linc-POU3F3, colorectal cancer, proliferation, apoptosis, signal pathway Received: June 18, 2015      Accepted: September 24, 2015      Published: October 15, 2015 ABSTRACT Long intergenic noncoding RNAs (lincRNAs) play important roles in regulating the biological functions and underlying molecular mechanisms of colorectal cancer (CRC). Here, we investigated the association of linc-POU3F3 and prognosis in CRC. We demonstrated that linc-POU3F3 was overexpressed in CRC tissues and positively correlated with tumor grade and N stage. Inhibition of linc-POU3F3 resulted in inhibition of cell prol...