Tetraphenylphosphonium Tetrafluoroborate/1,1,1,3,3,3-Hexafluoroisopropanol (Ph 4 PBF 4 /HFIP) Effecting Epoxide-Initiated Cation–Olefin Polycyclizations

作者：Yan Tian, Xin Xu, Lin Zhang, Jin Qu · 发表于：Organic Letters · 年份：2016 · DOI：10.1021/acs.orglett.5b03438 · 被引用次数：97 · 研究领域：Synthetic Organic Chemistry Methods、Asymmetric Synthesis and Catalysis、Chemical Synthesis and Reactions

The use of an excess amount of tetraphenylphosphonium tetrafluoroborate in 1,1,1,3,3,3-hexafluoroisopropanol, which can stabilize the intermediate cation in the reaction, efficiently promoted epoxide-initiated cation-olefin polycyclization reactions with broad functional group tolerance and water and oxygen tolerance.