Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy

作者：Sijumon Kunjachan, Alexandre Detappe, Rajiv Kumar, Thomas Ireland, Lisa Cameron, Douglas E. Biancur, Vincent Motto‐Ros, Lucie Sancey, Srinivas Sridhar, G. Mike Makrigiorgos, Ross Berbeco · 发表于：Nano Letters · 年份：2015 · DOI：10.1021/acs.nanolett.5b03073 · 被引用次数：151 · 研究领域：Nanoplatforms for cancer theranostics、MRI in cancer diagnosis、Radiation Therapy and Dosimetry

More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.