Enantioselective Synthesis of Atropisomeric Vinyl Arene Compounds by Palladium Catalysis: A Carbene Strategy

作者：Jia Feng, Bin Li, Yun He, Zhenhua Gu · 发表于：Angewandte Chemie International Edition · 年份：2015 · DOI：10.1002/anie.201509571 · 被引用次数：226 · 研究领域：Axial and Atropisomeric Chirality Synthesis、Algebraic structures and combinatorial models、Sphingolipid Metabolism and Signaling

An efficient palladium-catalyzed asymmetric synthesis of axially chiral vinyl arenes from aryl bromides and hydrazones is reported. The products were easily oxidized to axially chiral biaryl compounds, and the phosphine oxides were readily reduced to phosphine ligands.