The Diagnostic Efficacy and Biological Effects of microRNA-29b for Colon Cancer

作者：Leping Li, Ying Guo, Yuezhi Chen, Jinshen Wang, Zhen Lei, Xiaobo Guo, Jinglei Liu, Changqing Jing · 发表于：Technology in Cancer Research & Treatment · 年份：2015 · DOI：10.1177/1533034615604797 · 被引用次数：35 · 研究领域：MicroRNA in disease regulation、Circular RNAs in diseases、Extracellular vesicles in disease

BACKGROUND: Colorectal cancer is one of the most common cancers worldwide in terms of both incidence and mortality. The associations of expressions of tissue and plasma miR-29b were not detected in this study. METHODS: There are 400 healthy age- and gender-matched controls enrolled in this study in a rate of 1:2. The receiver operating characteristic curve analysis was undertaken using the expression level for miR-29b in the colorectal cancer specimens from patients with cancer and healthy controls to assess the diagnostic accuracy of both tissue and plasma miR-29b levels. RESULTS: It was found that the expression of plasma miR-29b is associated with the tissue miR-29b. Advanced study showed that aberrant miR-29b expression in both cancer tissues and plasma is associated with the clinicopathological data of patients with colorectal cancer. Tissue miR-29b showed an AUC of 0.883, with a sensitivity of 81.6% and a specificity of 84.9%. However, the AUC for plasma miR-29b was 0.743, with a sensitivity of 61.4% and a specificity of 72.5%. The analyses of the biological effects of miR-29b for colorectal cancer showed that miR-29b could inhibit the cell viability and migration. CONCLUSION: In summary, our data suggest that both the tissue and the plasma miR-29b levels have some value as a diagnostic tool for colorectal cancer. Advanced biological effects were conducted to detect the potential effect on the cell viability and migration. Future investigations including larger patient ...