Not all the number of skeletal muscle fibers is determined prenatally

作者：Mingsen Li, Xingyu Zhou, Yaosheng Chen, Yaping Nie, Huaxing Huang, Hu Chen, Delin Mo · 发表于：BMC Developmental Biology · 年份：2015 · DOI：10.1186/s12861-015-0091-8 · 被引用次数：26 · 研究领域：Muscle Physiology and Disorders、Aquaculture Nutrition and Growth、Birth, Development, and Health

BACKGROUND: The investigation of skeletal muscle development is of importance in stock farming and biomedicine. It is still ambiguous that whether animals are born with the full set of skeletal muscle fibers or if the number of myofibers continues to increase postnatally. RESULTS: Here, an inducible lineage-tracing system was employed to monitor the changes of myofiber number in various skeletal muscles during development. We confirm that the total myofiber number of longissimus dorsi, gastrocnemius and rectus femoris is determined prenatally. However, tibialis anterior and extensor digitorum longus have a different development pattern, and their myofiber number still increases in the first postnatal week and then remains stable afterwards. CONCLUSIONS: Our results highlight different development time frames of anatomically distinct skeletal muscles.